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KMID : 1145520160020020113
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Journal of Radiopharmaceuticals and Molecular Probes
2016 Volume.2 No. 2 p.113 ~ p.117
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Simple synthesis of [11C]DASB in HPLC loop and small animal PET imaging study
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Lee Bo-Eun
Cho Yong-Hyun
Lee Yun-Sang
Jeong Jae-Min
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Abstract
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As a neurotransmitter, serotonin plays important roles in brain. It relates various neuropsychiatric disorders such as anxiety, depression, schizophrenia. [11C]DASB is a well-known PET tracer for serotonin transporter imaging. In this study, we synthesized [11C]DASB in HPLC loop for simple and rapid production. Total synthesis time was about 40 minutes and the radiochemical purities were over 99%. The specific activity was 51.4 GBq/μmole (n=16). [11C]DASB showed highest uptake in mid-brain that serotonergic nerves are abundant and lowest uptake in cerebellum. In conclusion, we used HPLC loop method for [11C]DASB labeling and this method is useful for production of 11C labeled PET tracers.
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KEYWORD
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[11C]DASB, Loop method, Serotonin transporter, Positron emission tomography
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